@Jamesmor Welcome to the thread.
From what I can tell the error is being tripped when the gameguard files in active memory are scanned, that is why it is a timeable event. I watched it happen in real-time the other day by running a memory scan with PSO2 running. as soon as the scan hits the gameguard files PSO2 throws the NP1013 error. It is not that the Antivirus is even registering the files as a virus just the act of scanning the files seems to be the trigger.