This is a very sci fi setting with high levels of technology, remember Clarke's laws. The first states if a respected scientist says something is impossible he is most likely wrong, and if he says something is theoretically possible he is most likely correct.
the 3rd of course is the most famous, any sufficiently advanced tech is indistinguishable from magic (to those who dont understand how it works)
I would not be surprised if organic races had an average lifespan of over 200, with CASTS having that almost doubled in some cases.
Synthetic life would not be too difficult to create, and with the Hi CASTs we see its definitely possible.
The attempts that failed badly were trying to recreate the literal librarian computer goddess to all information of the multiverse, copying that is far far beyond what is required to copy a normal life form.
as for surviving in space... All characters, organic or otherwise seem to have some sort of photon based life support system which is not apparent from their clothing. We regularly are out in space without an EV suit, so clearly theres some kind of advanced photon tech for life support.