Every week, at some point, the game will not launch due to "missing files". The only option I've found that works is to uninstall/reinstall the game. Tried doing this today but have been unsuccessful. Any tips or solutions would be grateful.

Have you tried removing all of the C:\Program Files\ModifiableWindowsApps\pso2_bin files and restarting the computer?

Deleted all files and was able uninstall/reinstall.