I CERTAINLY HOPE NOT! that would be incredibly lame and jarring. Normal people and normal society uses pronouns and thus people expect it to be used.
Of course people should be called by the pronoun they feel most comfortable with, but the fact is that more times than not it matches the gender they were born as, not that theres anything wrong when it doesn't.
Not using pronouns at all would cause the writing to feel awfully strange and half finished, and detract hugely from the storyline, definitely destroying any chance NGS has to do better with story (PSo2 never had anything approaching good writing lol, it was all ham and cheese and fun times, not a bad thing but could be better)
It's either use standard pronouns or let us choose. it's not a valid option to just leave them all out so not to be "offensive" to the paper thin egos of certain radicals within minority groups who are constantly, sadly, looking for ways to feel offended.
No offense, but every group has its own radicals, and among the non-traditional gender groups they have theirs just as the aethists have theirs, the religious have theirs, and the pizza lovers have theirs (I'm sure you've heard of the pineapple heresy riots)